Trailing 1-0 from the semi-final first leg, Chelsea turned the tie on its head with goals by N'Golo Kante and Eden Hazard in the first half but Fernando Llorente struck for Spurs in an enthralling Stamford Bridge duel.
Manchester City chalked up yet another victory to maintain their stranglehold of the Premier League title race but pursuers Manchester United and Leicester City both secured important wins to enhance their top-four bids on Sunday.
Liverpool manager Juergen Klopp has a midfield conundrum and his Tottenham counterpart Mauricio Pochettino must decide whether Harry Kane is ready for action as both bosses face selection dilemmas for Saturday's Champions League final.
Federico Valverde finished off a stunning move in extra time to give Real Madrid a 3-2 victory over arch-rivals Barcelona
A summary of Saturday's matches in the English Premier League.
Tottenham Hotspur routed Bournemouth 5-0 as they leapfrogged City into second place in the league, six points behind leaders Liverpool who thrashed Newcastle United 4-0.
Substitute Neymar scored two second-half goals to inspire Brazil to a 4-1 win over the United States in Massachusetts on Tuesday.
An early goal by Guingamp's Jeremy Pied was enough to hand champions Paris St Germain their first loss of the French Ligue 1 season, leaving Olympique de Marseille still on top despite their own defeat by Monaco on Sunday.
Images from the English Premier League matches played on Saturday.
A preview of the line-up action in the English Premier League.
Olympiakos Piraeus battled back from a two-goal deficit to earn a 2-2 home draw with last year's runners-up Tottenham Hotspur in their Champions League Group B opener.
Jose Mourinho, sacked by Manchester United last season after his reign there turned sour, has been charm personified since swapping punditry for the Tottenham job.
While the lack of squad-strengthening is causing consternation amongst the fans, Tottenham's squad is still young and looks more than capable of standing its ground.
Manchester United and Tottenham Hotspur built hefty leads with emphatic away wins in their Europa League last 32 first-leg matches but AC Milan were held to a 2-2 draw at Red Star Belgrade as the competition resumed on Thursday.
Manchester City moved back to second in the Premier League after a stylish 3-0 win over Everton at the Etihad Stadium on Sunday as Pep Guardiola's side responded to convincing Chelsea and Liverpool wins with a reminder of their class.
Premier League Leeds United suffered the biggest upset of the FA Cup third round when they fell to a 3-0 defeat by fourth-tier Crawley Town on Sunday
Chelsea beat Arsenal 3-2 in a pulsating London English Premier League derby on Saturday with defender Marcos Alonso scoring an 81st-minute winner after the Gunners had fought back from an early 2-0 deficit.
Sergio Aguero struck twice as Manchester City moved into second place in the Premier League, two points behind leaders Liverpool, with a 3-1 win at Bournemouth on Sunday. Just three weeks into the new season and last year's top two clubs are already perched at the top of the table.
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
Eight time champions Brazil were held 0-0 by Ecuador in the glamour game as the second day of the centenary Copa America tournament mustered up only one, albeit spectacular, goal from three matches on Saturday.
Eriksen punctured Brighton's armour from Tottenham's 29th goal attempt -- 21 of which were from outside the penalty area.
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
Images from Sunday's action in the Premier League.
Steven Bergwijn scored twice in stoppage time as Tottenham Hotspur stunned Leicester City and pulled off a remarkable 3-2 victory in the Premier League on Wednesday.
Tottenham Hotspur climbed to third with a 3-1 win over Southampton while Chelsea hung on to fourth spot, above Arsenal on goal difference, despite a 2-1 defeat at Wolverhampton Wanderers.
West Ham United's hopes of avoiding relegation suffered a cruel blow as an own goal by midfielder Tomas Soucek and Harry Kane's first goal since December condemned them to a 2-0 defeat at Tottenham Hotspur on Tuesday.
Liverpool took a giant step towards their first title since 1990 on Saturday when their 3-0 win at Bournemouth combined with Manchester United's 2-1 victory at Manchester City to leave the champions 14 points adrift of the Premier League leaders.
Images from the English Premier League matches played on Wednesday night.
A summary of Sunday's action in the Premier League.
Llorente's second-half treble, a double from Son Heung-min and a late effort from Kyle Walker-Peters in driving snow at a freezing Wembley Stadium settled an game where tensions had threatened to bubble over before the break.
Images from Sunday's action in the Premier League.
Christian Eriksen kept Tottenham Hotspur's hopes of completing a remarkable salvage job and reaching the last 16 of the Champions League alive with a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
'So, the Champions League final will be played between two teams who just don't know when they are beaten,' says Suhit K Sen.
Check out the top footballers of the weekend...
Tottenham moved up to seventh place with 36 points from 22 games
Images from the EPL matches played on Sunday
News of all that's transpired on and off the football field
Images from the Champions League matches played on Tuesday
News of all that transpired on and off the football field.
Thomas Meunier volleyed a spectacular last-minute goal to give Paris St Germain a 2-1 win at FC Basel, which took them into the last 16 of the Champions League on Tuesday.